BDBM158154 US10081622, Compound 11::US10370379, Entrectinib::US11059827, Compound Entrectinib::US11267806, Compound T-12::US9029356, 11::US9255087, 11::US9616059, 11
SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1
InChI Key InChIKey=HAYYBYPASCDWEQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 55 hits for monomerid = 158154
Affinity DataKi: 6.20nMAssay Description:Inhibition of recombinant ALK (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human TEL (336 residues) fused-ROS1 (1891 to 2347 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKA (440 to 796 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKB (455 to 822 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKC (454 to 825 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human TRKB incubated for 90 mins by selectscreen kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human TRKC incubated for 90 mins by selectscreen kinase assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of ROS1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of ACK1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 122nMAssay Description:Inhibition of IGF1R (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of FAK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 164nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of BRK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 209nMAssay Description:Inhibition of IR (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of AUR2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 349nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 393nMAssay Description:Inhibition of RET (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of VEGFR3 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of KIT (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of AUR1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ABL (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PKCbeta (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2/CycA (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SYK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDC7/DBF4 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EEF2K (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MELK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MET (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MPS1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST4 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase NIM1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NIM1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair