BDBM192714 US11725011, Compound YKL-05-95::YKL-05-095 (3)

SMILES COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)c1c(C)cccc1Cl

InChI Key InChIKey=VGLSPBMOSOBBBC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192714   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))
Affinity DataIC50:  6nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))
Affinity DataIC50:  6nMAssay Description:IC50's for selected compounds in Table 5 below were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))
Affinity DataEC50:  11nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed