BDBM19442 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol::2-(4-methoxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1-benzothiophen-6-ol::Arzoxifene

SMILES COc1ccc(cc1)-c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=MCGDSOGUHLTADD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19442   

TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  21.5nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  66.3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataEC50:  0.200nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  240nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-beta (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  42nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-alpha (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed