BindingDB BDBM21025 (2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid::(D-Ala2,D-Leu5)-Enkephalin::BW-180C::CHEMBL340032::DADLE::DADLE-OH::H-Tyr-D-Ala-Gly-Phe-D-Leu-OH::[D-Ala2-D-Leu5]enkephalin

BDBM21025 (2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid::(D-Ala2,D-Leu5)-Enkephalin::BW-180C::CHEMBL340032::DADLE::DADLE-OH::H-Tyr-D-Ala-Gly-Phe-D-Leu-OH::[D-Ala2-D-Leu5]enkephalin

SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=ZHUJMSMQIPIPTF-IBURTVSXSA-N

Data 31 KI 15 IC50 5 Kd 6 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 21025

Delta-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 0.180nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Delta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 0.260nMAssay Description:Binding affinity against Opioid receptor delta 1 in P2 membrane preparation of rat brain by [3H]DADLE displacement.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Delta-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 0.300nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Delta-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 0.700nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Delta-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 0.740nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Delta-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.30nM ΔG°: -12.1kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Mu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.65nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Opioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.80nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.80nMMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Delta-type opioid receptor(MOUSE)
Stanford University

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.83nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Delta-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.90nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 2.49nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 2.85nMMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(GUINEA PIG)
Nanjing Medical University

Curated by ChEMBL

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 3.20nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 1 hrMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Mu-type opioid receptor(GUINEA PIG)
Nanjing Medical University

Curated by ChEMBL

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 3.20nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 4.90nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(CALF)
Stanford University

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 5.10nMMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Delta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 7.70nMAssay Description:Inhibition of [3H]DSLET binding to delta 1 opioid receptors in rat brain membranesMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 8.20nMAssay Description:Binding affinity against Opioid receptor mu 1 in P2 membrane preparation of rat brain by [3H]DAGO displacement.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 8.40nMAssay Description:Ability to inhibit the binding of [3H]-DAGO to Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Opioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 9.70nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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Kappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 10.2nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(CALF)
Stanford University

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 14.2nMMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 15nM ΔG°: -10.7kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article PubMed

Mu-type opioid receptor(GUINEA PIG)
Nanjing Medical University

Curated by ChEMBL

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 15.6nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 16nMMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Kappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Kappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sigma non-opioid intracellular receptor 1(RAT)
TBA

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed

Kappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Sri International

Curated by PDSP K_i Database

PNG

BDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Filter my 57 hits

Targets 6▿
- Mu-type opioid receptor 25
- Delta-type opioid receptor 19
- Kappa-type opioid receptor 7
- Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 3
- Opioid receptor delta 1 2
- Sigma non-opioid intracellular receptor 1 1
- ...
Publications 19▿
- J Pharmacol Exp Ther 214: 395-402 (1980) 7
- NIDA Res Monogr 178: 440-66 (1998) 6
- J Med Chem 39: 2081-6 (1996) 5
- Bioorg Med Chem 22: 2208-19 (2014) 5
- J Med Chem 29: 531-7 (1986) 5
- J Med Chem 38: 1523-37 (1995) 4
- Mol Pharmacol 45: 330-4 (1994) 3
- Eur J Med Chem 168: 189-198 (2019) 3
- J Pharmacol Exp Ther 270: 1246-55 (1994) 3
- J Pharmacol Exp Ther 286: 1007-13 (1998) 2
- J Med Chem 31: 374-83 (1988) 2
- Mol Pharmacol 31: 326-33 (1987) 2
- J Med Chem 24: 1119-24 (1982) 2
- J Med Chem 50: 2779-86 (2007) 2
- J Med Chem 34: 1350-5 (1991) 2
- J Med Chem 29: 1861-4 (1986) 1
- J Med Chem 27: 115-20 (1984) 1
- RSC Med Chem 11: 896-904 (2020) 1
- Proc Natl Acad Sci U S A 81: 4983-7 (1984) 1
Institutions 13▿
- TBA 10
- National Institute Of Diabetes And Digestive And Kidney Diseases 9
- Stanford University 7
- Sri International 6
- Nanjing Medical University 5
- Memorial Sloan-Kettering Cancer Center 5
- University of Pennsylvania 3
- University Of Catania 3
- University Of Paris 2
- University of Arizona Tucson 2
- Burroughs Wellcome 2
- National Institute Of Environmental Health Sciences 2
- National Institute On Drug Abuse 1
Affinity: 0.020 to 1.0E+4 nM▿
- Ki 31
- IC50 15
- Kd 5
- EC50 6
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1