BDBM21173 1,3-dipropyl-8-cyclopentylxanthine::8-cyclopentyl-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::CHEMBL183::DPCPX::PD116948::[3H]DPCPX
SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CCCC1
InChI Key InChIKey=FFBDFADSZUINTG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 265 hits for monomerid = 21173
Affinity DataKd: 3nMpH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/...More data for this Ligand-Target Pair
Affinity DataKd: 30nMpH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug) were incubated at 25 °C for 90 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mm MgCl2, 2 units/mL ADA, pH...More data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of [3H]NECA specific binding against Adenosine A2 receptors of rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 656nMAssay Description:Compound was evaluated for inhibition of adenosine induced relaxation against guinea-pig aorta (Adenosine A2 receptor).More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Binding affinity against human A1 receptor (hA1) was measured through displacement of [3H]DPCPX using yeast cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 261nMAssay Description:Inhibitory activity against membranes from HEK293 cells stably expressing the human A2a receptor (hA2a)More data for this Ligand-Target Pair
Affinity DataIC50: 261nMAssay Description:Inhibitory activity against membranes from HEK293 cells stably expressing the human A2a receptor (hA2a)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against human A1 receptor (hA1) on membranes from yeast cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor) at 10 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibitory activity against Adenosine A1 Receptor using [3H]CHA in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against Adenosine A2a receptor using [3H]NECA in rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Antagonist activity at adenosine A1 receptor in rat cortical membrane assessed as reduction of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of [3H]-CHA binding against Adenosine A1 receptors of rat cortical membranes; Not testedMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-1210...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 132nMAssay Description:Antagonist activity at human A2AR expressed in CHO cells assessed as inhibition of CGS21680-stimulated cAMP production by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Inverse agonist activity at human A1AR expressed in CHO cells assessed as increase in forskolin-stimulated cAMP production by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 933nMAssay Description:Antagonist activity at human wild type A1R expressed in CHO-K1 cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measur...More data for this Ligand-Target Pair
Affinity DataKi: 0.155nMAssay Description:Displacement of [3H]CPX from Adenosine A1 receptor of bovine brain cerebral cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.155nMAssay Description:Displacement of [3H]CPX from Adenosine A1 receptor of bovine brain cerebral cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.211nMAssay Description:Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat brain cortical membranes in presence of 0.1 mM GTPMore data for this Ligand-Target Pair
Affinity DataKi: 0.229nMAssay Description:Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat brain cortical membranes in absence of GTPMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]cyclohexyladenosine (CHA).More data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Binding affinity against adenosine A1 receptor in bovine cortical membranes using [3H]CHA as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.282nMAssay Description:Adenosine A1 receptor binding using [3H]DPCPX in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]-PIA from Adenosine A1 receptor in Wistar rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Affinity to A1 adenosine receptor was measured by the displacement of [3H]PIA in bovine brain cortical membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]PIA from adenosine A1 receptors of rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity for Adenosine A1 receptor using [3H]- CHA or [3H]- PIAMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]cyclohexyladenosineMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity at bovine Adenosine A1 receptor.More data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]CHA from adenosine A1 receptor derived from rat brain membrane assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.470nMAssay Description:Antagonist activity against adenosine A1 receptor in human plateletsMore data for this Ligand-Target Pair