BDBM21340 6-aza-UMP::C6-Uridine Derivative, 18::{[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O

InChI Key InChIKey=LRVZOSYMNMNQFR-SHUUEZRQSA-N

Data  5 KI

PDB links: 23 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 21340   

TargetOrotidine 5'-phosphate decarboxylase(Saccharomyces cerevisiae)
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM21340(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)
Affinity DataKi:  64nMAssay Description:Inhibition of Saccharomyces cerevisiae ODCase at 25 degreeC by competitive binding assayMore data for this Ligand-Target Pair
TargetOrotidine-5'-phosphate decarboxylase(Plasmodium falciparum (malaria parasite P. falcipa...)
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM21340(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of Plasmodium falciparum ODCase at 25 degreeC by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrotidine-5'-phosphate decarboxylase(Plasmodium falciparum (malaria parasite P. falcipa...)
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM21340(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.45kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21340(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)
Affinity DataKi:  1.24E+4nM ΔG°:  -7.36kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21340(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)
Affinity DataKi:  1.24E+4nMAssay Description:Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assayMore data for this Ligand-Target Pair