BDBM21844 8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::Ro 64-6198
SMILES [H][C@@]12CCCc3cccc([C@@H](CC1)N1CCC4(CC1)N(CNC4=O)c1ccccc1)c23
InChI Key InChIKey=JLFMYEAXZNPWBK-NFBKMPQASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 21844
Affinity DataKi: 0.390nM ΔG°: -12.7kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Binding affinity to human nociceptin opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 89nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
Affinity DataKi: 1.38E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in human HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human nociceptin opioid receptor by GTPgamma(35)S binding assayMore data for this Ligand-Target Pair