BDBM21864 (21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.0^{1,13}.0^{2,21}.0^{4,12}.0^{5,10}.0^{19,25}]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol::(8R)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol::NALTRINDOLE::[3H]-naltrindole

SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34

InChI Key InChIKey=WIYUZYBFCWCCQJ-XEWUMVRVSA-N

Data  158 KI  8 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 21864   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM SNC-80 as the agonist ligand for delta-rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.0620nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DADLE from morphine-insensitive Opioid receptor delta 1 (presence of 50 nM morphine) of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]DADLE from Opioid receptor delta 1 of rat brain membranes (DAMGO quenching mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity to delta opioid receptor was measured using [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM DAMGO as the agonist ligand for mu-recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  3.20nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  6nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM U69,593 as the agonist ligand for kappa-re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  8.80nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]DADLE from morphine-sensitive Opioid receptor delta 1 (presence of 300 nM DELT-II) of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]OXY from Opioid receptor kappa 2b of guinea pig brain membranes (pretreated with BIT(mu) and FIT(delta) and in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranes (pretreated with BIT and FIT to block mu and delta sites)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  36nMAssay Description:Binding affinity for kappa opioid receptor was measured using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  36nMAssay Description:Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]DAMGO from Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  75nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  99nMAssay Description:Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  99nMAssay Description:Binding affinity to mu opioid receptor was measured using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  151nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed