BDBM221688 US10568884, Cpd 9::US9314464, 9::US9593100, Compound 9::USRE49556, Compound 9

SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C

InChI Key InChIKey=CMJCXYNUCSMDBY-ZDUSSCGKSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221688   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM221688(US10568884, Cpd 9 | US9314464, 9 | US9593100, Comp...)
Affinity DataIC50:  0.300nMAssay Description:B-Raf (V600E; 4 pM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgC...More data for this Ligand-Target Pair
In DepthDetails US Patent