BDBM22334 BW A4C::BW4C::BWA4C::BWA4C, 10::CHEMBL314360::JMC515449 Compound 7::N-(3-phenoxycinnamyl)acetohydroxamic acid::N-hydroxy-N-[(2E)-3-(3-phenoxyphenyl)prop-2-en-1-yl]acetamide

SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1

InChI Key InChIKey=CEUDWZXMLMKPNN-UHFFFAOYSA-N

Data  38 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 22334   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 110nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 160nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human neutrophils assessed as inhibition of enzyme product formation by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-LO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 220nMAssay Description:Inhibition of 5-LO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 110nMAssay Description:Inhibition of 5-LO in PMNL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 3.20E+3nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase from human polymorphsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 140nMAssay Description:Inhibition of 5-lipoxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LO in human leucocytes by measuring FLAP-dependent 5-LOproduct LTB4 in presence of calcium ionophore A23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 150nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetLipoxygenase(Potato)
The University of Sydney

LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 1.71E+4nMAssay Description:A colorimetric 5-LO assay kit (Lipoxygenase Inhibitor Screening Assay Kit) and potato 5-LO isolate were purchased from Cayman Chemicals (Ann Arbor, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 140nMAssay Description:In vitro inhibition of 5-lipoxygenase from human polymorphsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 100000g supernatants, aliquots of the supernatants were added to reaction mix, and were preincubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using arachidonic acid as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 110nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 140nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed