BDBM22334 BW A4C::BW4C::BWA4C::BWA4C, 10::CHEMBL314360::JMC515449 Compound 7::N-(3-phenoxycinnamyl)acetohydroxamic acid::N-hydroxy-N-[(2E)-3-(3-phenoxyphenyl)prop-2-en-1-yl]acetamide
SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI Key InChIKey=CEUDWZXMLMKPNN-SOFGYWHQSA-N
Data 38 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 22334
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Eberhard Karls University Tuebingen
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 100000g supernatants, aliquots of the supernatants were added to reaction mix, and were preincubated wit...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Eberhard Karls University Tuebingen
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using using arachidonic acid a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Eberhard Karls University Tuebingen
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Eberhard Karls University Tuebingen
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Eberhard Karls University Tuebingen
Affinity DataIC50: 110nMAssay Description:Inhibition of 5-LO in PMNL cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Eberhard Karls University Tuebingen
Curated by ChEMBL
Eberhard Karls University Tuebingen
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Eberhard Karls University Tuebingen
Curated by ChEMBL
Eberhard Karls University Tuebingen
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair