BDBM22334 BW A4C::BW4C::BWA4C::BWA4C, 10::CHEMBL314360::JMC515449 Compound 7::N-(3-phenoxycinnamyl)acetohydroxamic acid::N-hydroxy-N-[(2E)-3-(3-phenoxyphenyl)prop-2-en-1-yl]acetamide
SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI Key InChIKey=CEUDWZXMLMKPNN-SOFGYWHQSA-N
Data 38 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 22334
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LO in human leucocytes by measuring FLAP-dependent 5-LOproduct LTB4 in presence of calcium ionophore A23187More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and ...More data for this Ligand-Target Pair