BDBM23738 2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetamide::CHEMBL346855::Indole Derivative, 1

SMILES COc1ccc2n(Cc3ccccc3)c(C)c(CC(N)=O)c2c1

InChI Key InChIKey=RUPYVFAPAMOERU-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23738   

TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Peking University

LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50:  540nMpH: 8.0 T: 2°CAssay Description:Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Tanabe Research Laboratories Usa

LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataEC50:  1.50E+3nMAssay Description:Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Peking University

LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50:  840nMAssay Description:Inhibition of Human Nonpancreatic Secretory Phospholipase A2 through Chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human LTA4H aminopeptidase activity using Ala-p-nitroanilide as substrate incubated for 2 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Peking University

LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50:  880nMAssay Description:Inhibition of human nonpancreatic secretory phospholipase A2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine as substrate after 10 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Peking University

LigandPNGBDBM23738(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human non-pancreatic sPLA2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine substrate after 5 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed