BDBM24523 (2E,5E)-2-{[4-(adamantan-1-yl)-1,3-thiazol-2-yl]imino}-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one::Thiazole analogue, 10

SMILES COc1cc(\C=C2\S\C(NC2=O)=N\c2nc(cs2)C23CC4CC(CC(C4)C2)C3)ccc1O

InChI Key InChIKey=XSYJDILFFHLZSW-UFWORHAWSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24523   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24523((2E,5E)-2-{[4-(adamantan-1-yl)-1,3-thiazol-2-yl]im...)
Affinity DataKi:  1.23E+4nM ΔG°:  -6.69kcal/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed