BDBM24529 (2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one::2-(benzo[d]isothiazol-3-ylimino)-5-benzylidenethiazolidin-4-one, 4b::Benzisothiazole analogue, 16

SMILES COc1ccc(\C=C2\S\C(NC2=O)=N/c2nsc3ccccc23)cc1

InChI Key InChIKey=CUYKYRMAYZIOKD-XNTDXEJSSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24529   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24529((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...)
Affinity DataKi:  2.28E+4nM ΔG°:  -6.33kcal/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM24529((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...)
Affinity DataIC50:  36nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM24529((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...)
Affinity DataIC50:  36nMpH: 7.0 T: 2°CAssay Description:The MMP assay were performed evaluating the ability of compounds 1a-6a and 1b-6b to prevent the hydrolysis of the fluorescence-quenched peptide subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed