BDBM24603 3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]urea::Benzimidazole urea analogue, 7

SMILES CCNC(=O)Nc1nc2cc(c(C)cc2[nH]1)-c1cccnc1

InChI Key InChIKey=PCWGVOYQPPLYQR-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24603   

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  61nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandPNGBDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  85nM ΔG°:  -9.80kcal/molepH: 7.5 T: 30°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  1.40E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed