BDBM25150 (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide::Belinosta::Belinostat::PXD-101::PXD101
SMILES c1ccc(cc1)NS(=O)(=O)c2cccc(c2)/C=C/C(=O)NO
InChI Key InChIKey=NCNRHFGMJRPRSK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 127 hits for monomerid = 25150
Affinity DataKi: 0.900nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Affinity DataKi: 1.10nM ΔG°: -12.2kcal/mole IC50: 1.90nMT: 2°CAssay Description:The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC in human HeLa cell extractsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of purified recombinant HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC in human HeLa cell extractsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human full length HDAC1 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of HDAC1/2 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition mea...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extracts incubated for 30 mins by fluorescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Human)
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair