BDBM25150 (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide::Belinosta::Belinostat::PXD-101::PXD101

SMILES ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1

InChI Key InChIKey=NCNRHFGMJRPRSK-MDZDMXLPSA-N

Data  21 KI  67 IC50  9 EC50  1 Other

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 25150   

TargetHistone deacetylase 6(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  15nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  25nMAssay Description:Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  51nMAssay Description:Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  59nMAssay Description:Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataIC50:  63nMAssay Description:Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed