BDBM268608 (R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4,4-dimethyl-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-1H-imidazol-5(4H)-one ::US10413545, Compound 2::US9718813, Compound 2
SMILES Cn1ncc2cc(ccc12)-c1ccc(cc1)C1=NC(C)(C)C(=O)N1C[C@@H]1CCN(C1)C(=O)C1CC1
InChI Key InChIKey=DECUYALVQMJPQR-GOSISDBHSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 268608
Affinity DataIC50: 141nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Affinity DataIC50: 141nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human full length FASN using [3H]-acetyl-CoA/malonyl-CoA as substrate after 60 mins in presence of NADPH by scintillation proximity ass...More data for this Ligand-Target Pair
Affinity DataIC50: 708nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair