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Found 3 Enz. Inhib. hit(s) with Target = 'Fatty acid synthase' and Ligand = 'BDBM268608'
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM268608((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human full length FASN using [3H]-acetyl-CoA/malonyl-CoA as substrate after 60 mins in presence of NADPH by scintillation proximity ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM268608((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50:  141nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM268608((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50:  141nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent