BDBM288469 4-(8-amino-1-(4-((4- cyanopyridin-2- yl)carbamoyl)-2- fluorophenyl)imidazo [1,5-a]pyrazin-3- yl)cubane-1- carboxylic acid::US10087188, Example 76

SMILES Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C#N)c12)C12C3C4C1C1C2C3C41C(O)=O

InChI Key InChIKey=ILNNMAHAXXPJPF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288469   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288469(4-(8-amino-1-(4-((4- cyanopyridin-2- yl)carbamoyl)...)
Affinity DataIC50:  0.410nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent