BDBM295011 US10112922, Compound 1::US9926299, 27 (R-isomer)

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)S(=O)(=O)C=C

InChI Key InChIKey=ZBSNMQMIMASYNG-QGZVFWFLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 295011   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295011(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295011(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Affinity DataIC50: <100nMAssay Description:Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295011(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Affinity DataIC50: <100nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent