BDBM307625 N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl)pyridin-2-yl)-1- oxoisoindoline-5- carbonyl)piperidin- 4-yl)acetamide::US10150755, Compound 17

SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1

InChI Key InChIKey=VVPITATYRITTEY-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 307625   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307625(N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl...)
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307625(N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl...)
Affinity DataIC50: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307625(N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307625(N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent