BDBM31462 substituted biphenyl derivative, 36b

SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(C=C)cc1C(=O)Nc1ccc(cc1)C(N)=N

InChI Key InChIKey=FCTCJAGJUHHZDO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31462   

TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50:  9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50:  1.65E+3nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50:  9.40E+3nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biocryst Pharmaceuticals

LigandPNGBDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50:  470nMT: 2°CAssay Description:Trypsin assay reactions were performed in a mixture containing trypsin, and test compounds were added at varied concentrations. The reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed