BDBM31524 5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide (I-1)::AKOS015840255::GRL0617::Naphthalene and Benzamide Derivative, 25::SARS-CoV-2 PLpro Inhibitor, GRL0617 (1)::med.21724, Compound 159

SMILES C[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12

InChI Key InChIKey=UVERBUNNCOKGNZ-CQSZACIVSA-N

Data  15 IC50  2 Kd  2 EC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31524   

TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataEC50:  2.76E+4nMAssay Description:Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataEC50: >2.00E+4nMAssay Description:A549-hACE2 cells were seeded 1.5 × 105 cells/well in DMEM complete into 24-well plates (0.5 mL/well) and then incubated for 16 h at 37 °C and 5% CO2....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed