BDBM320423 2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,2-b]- pyridine-7-carboxylic acid::US10174026, Example 88::US9738637, Example 88

SMILES CCCOC(c1cc2nccc(C(O)=O)c2[nH]1)c1ccccc1Cl

InChI Key

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320423   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quantical Research

US Patent
LigandPNGBDBM320423(2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quantical Research

US Patent
LigandPNGBDBM320423(2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quantical Research

US Patent
LigandPNGBDBM320423(2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,...)
Affinity DataKd:  530nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quantical Research

US Patent
LigandPNGBDBM320423(2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using biotinylated H3K4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quantical Research

US Patent
LigandPNGBDBM320423(2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,...)
Affinity DataIC50:  5.50E+3nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent