BDBM32135 4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-ylidene]cyclohexa-2,5-dien-1-one::4-[4-(3,4-dihydroxyphenyl)-3H-thiazol-2-ylidene]-1-cyclohexa-2,5-dienone::4-[4-(3,4-dihydroxyphenyl)-4-thiazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[4-[3,4-bis(oxidanyl)phenyl]-3H-1,3-thiazol-2-ylidene]cyclohexa-2,5-dien-1-one::MLS000111214::SMR000107140::cid_5406370

SMILES Oc1ccc(cc1)-c1nc(cs1)-c1ccc(O)c(O)c1

InChI Key InChIKey=FSQMZTBSNBWMOW-UHFFFAOYSA-N

Data  4 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 32135   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataIC50:  740nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
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TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50:  1.31E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
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TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50:  6.35E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50:  1.20E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataIC50: >3.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
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TargetLarge T antigen(Simian virus 40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50: >5.00E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
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TargetEstrogen receptor beta(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataIC50:  9.07E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
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TargetEstrogen receptor beta(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataIC50:  4.96E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPOsterior Segregation(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50:  3.35E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
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TargetZinc finger protein mex-5(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50:  2.08E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
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TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM32135(4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-yliden...)
Affinity DataEC50: <195nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay