BDBM35052 K00152::US10047093, 8-39::US10392392, Example 8-39::US10875864, EX. 8-39::US9416132, 8-39

SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12

InChI Key InChIKey=OEIWNDGDGDPXIO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 35052   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  7.10E+3nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50: >3.00E+4nMAssay Description:hERG activity assays representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent