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Found 5 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM35052'
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  48nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM35052(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed