BDBM35861 phenylpropanoic acid analogue, 5

SMILES OC(=O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1

InChI Key InChIKey=SREGRCFSXVBPIJ-UHFFFAOYSA-N

Data  5 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 35861   

TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataKi:  12nM EC50:  22nMAssay Description:Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataKi:  1.10E+3nMAssay Description:Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataKi:  2.80E+3nMAssay Description:Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataKi:  7.10E+3nM ΔG°:  -7.02kcal/molepH: 6.0 T: 2°CAssay Description:Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataIC50:  580nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataIC50:  3.60E+3nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataIC50:  580nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Ono Pharmaceutical

LigandPNGBDBM35861(phenylpropanoic acid analogue, 5)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed