BDBM35909 2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide::2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (hydroxy flutamide)::2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide(Hydroxyflutamide)::2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide::CHEMBL491::Eulexin::Hydroxyflutamide::OH-flutamide::Sch 16423::US9682960, OH-FLU::cid_91649::hydroxy-flutamide

SMILES CC(C)(O)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI Key InChIKey=YPQLFJODEKMJEF-UHFFFAOYSA-N

Data  9 KI  24 IC50  1 EC50

PDB links: 8 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 35909   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  2nMAssay Description:Binding affinity for mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  27nMAssay Description:Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  34nMAssay Description:Inhibitory concentration against human androgen receptor (AR) dependent transcriptional activity in cotransfected mammalian CV-1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  43nMAssay Description:Inhibition of [3H]-DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  43nMAssay Description:Binding affinity for androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  430nMAssay Description:Displacement of [3H]testosterone from wild type human androgen receptorMore data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataKi:  2.10E+3nMAssay Description:In vivo binding affinity for rat ventral prostate androgen receptor by displacement of [3H]R-1881More data for this Ligand-Target Pair