BDBM36485 1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol::Mps1-IN-1::US11208696, Example 30

SMILES COc1cc(ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1)N1CCC(O)CC1

InChI Key InChIKey=NMJMRSQTDLRCRQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 36485   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM36485(1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...)
Affinity DataIC50:  367nMpH: 7.5 T: 2°CAssay Description:ATP-site competition binding assay using Mps1 Kinase inhibitors in LanthaScreen Eu time-resolved FRET (TR-FRET) technology from Invitrogen.More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM36485(1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...)
Affinity DataIC50:  37.5nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM36485(1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair