BDBM389586 N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]vinyl}quinazolin- 4-yl)ethane-1,2-diamine::US9951029, 88

SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1

InChI Key InChIKey=GZTYTAOGJJGFNK-JLHYYAGUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 389586   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389586(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Affinity DataIC50:  461nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389586(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Affinity DataIC50:  340nMAssay Description:Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389586(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Affinity DataIC50:  480nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389586(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Affinity DataIC50:  6.78E+3nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed