BDBM397897 US9994552, Compound 108
SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
InChI Key InChIKey=GWVUCXTYNJIWGK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 397897
Affinity DataIC50: <1nMAssay Description:Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: <1nMAssay Description:Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of The Pacific
Curated by ChEMBL
University Of The Pacific
Curated by ChEMBL
Affinity DataKd: 8nMAssay Description:Binding affinity to PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 20nMAssay Description:Binding affinity to KIT (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 4.40nMAssay Description:Binding affinity to KIT V816H mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 0.400nMAssay Description:Binding affinity to KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to KIT V559D mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding affinity to KIT V559D/T670I mutant (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of The Pacific
Curated by ChEMBL
University Of The Pacific
Curated by ChEMBL
Affinity DataKd: 14nMAssay Description:Binding affinity to PDGFRalpha (unknown origin)More data for this Ligand-Target Pair