BDBM422082 US10508103, Embodiment 39

SMILES CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](F)C[C@H]1Cc1c([nH]c2cc(F)ccc12)-c1nc2cc(F)ccc2n1C[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C

InChI Key

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 422082   

TargetBaculoviral IAP repeat-containing protein 2 [253-363](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM422082(US10508103, Embodiment 39)
Affinity DataIC50: <10nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM422082(US10508103, Embodiment 39)
Affinity DataEC50:  55nMAssay Description:First day:Dilution of Compounds: 1) tested compounds were added into DMSO to give parent liquor (10 mM); 2) reference compound Birinapant (32 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM422082(US10508103, Embodiment 39)
Affinity DataIC50: <10nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 3 [238-349](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM422082(US10508103, Embodiment 39)
Affinity DataIC50:  55nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent