BDBM435762 2-(2,6-dichlorophenyl)-1- ((1S,3R)-5-(1-ethyl-1H- pyrazol-4-yl)-3- (hydroxymethyl)-1-methyl- 3,4-dihydroisoquinolin-2(1H)- yl)ethan-1-one::US10611751, Example 2

SMILES CCn1cc(cn1)-c1cccc2[C@H](C)N([C@@H](CO)Cc12)C(=O)Cc1c(Cl)cccc1Cl

InChI Key InChIKey=YYXGUZDGIAJZJN-DOTOQJQBSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435762   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM435762(2-(2,6-dichlorophenyl)-1- ((1S,3R)-5-(1-ethyl-1H- ...)
Affinity DataEC50:  172nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM435762(2-(2,6-dichlorophenyl)-1- ((1S,3R)-5-(1-ethyl-1H- ...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM435762(2-(2,6-dichlorophenyl)-1- ((1S,3R)-5-(1-ethyl-1H- ...)
Affinity DataEC50:  172nMAssay Description:Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed