BDBM453263 2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-acetyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide::US10729691, Example 48

SMILES CC(=O)N1CCc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2C1)-c1cccc(OCC(=O)NC(C)(C)C)c1

InChI Key InChIKey=RQGCWKKYDAVZGQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453263   

TargetPutative sugar transporter(Plasmodium falciparum)
Kadmon

US Patent
LigandPNGBDBM453263(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-acety...)
Affinity DataIC50:  55nMAssay Description:Parasite cultures were seeded in 96-well plates (1% hematocrit, 1-2% starting parasitemia, 100 μL total volume) with varying concentrations of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 2, facilitated glucose transporter member 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM453263(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-acety...)
Affinity DataIC50:  55nMAssay Description:HT1080 cells (as well as other cell types) were plated to confluency in 96-well plates. Cells were exposed to the combination of 10 μM Oligomyci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent