BDBM468316 4-{2-amino-4-[3- (6-cyclopropyl-8- fluoro-1-oxoisoquinolin- 2(1H)-yl)-2- (hydroxymethyl)phenyl]- 7H-pyrrolo[2,3- d]pyrimidin-6-yl}-N,N- dimethyl-5,6- dihydropyridine-1(2H)- carboxamide::US10793575, Example 87
SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(nc(N)nc2[nH]1)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C1CC1
InChI Key InChIKey=NFJBREDEMVGORP-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468316
Affinity DataIC50: 0.520nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair