BDBM491448 US10975056, Example 422::US11771711, Reference compound 4

SMILES CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccc(OC)cc2)nc(N2CC[C@H](O)C2)c1C#N

InChI Key InChIKey=JEFIUPIEKDPKGY-IFXJQAMLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 491448   

TargetDNA (cytosine-5)-methyltransferase 1 [601-1600](Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491448(US10975056, Example 422 | US11771711, Reference co...)
Affinity DataIC50:  79nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Human truncated DNMT1(601-1600),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491448(US10975056, Example 422 | US11771711, Reference co...)
Affinity DataIC50: <320nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent