BDBM50002755 11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid::CHEMBL114424

SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1

InChI Key InChIKey=GODBHXSVNOESLI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50002755   

TargetThromboxane A2 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataKi:  33nMAssay Description:Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataKi:  33nMAssay Description:Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataIC50:  2.20E+3nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed