BDBM50004665 (oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one::1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one::1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one (oxotremorphine)::1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one(Oxotremorine)::1-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-pyrrolidinium::CHEMBL7634::Oxotremorine::Oxotremorine1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one::cid_4630
SMILES O=C1CCCN1CC#CCN1CCCC1
InChI Key InChIKey=RSDOPYMFZBJHRL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 89 hits for monomerid = 50004665
Affinity DataKi: 0.5nMAssay Description:In vitro ability to displace 3H-cis-methyltrimethylammoniummethyl-1,3-dioxolane [3H]CD) from rat cortical Muscarinic acetylcholine receptor in compet...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]CD as a radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Compound was assessed for the binding affinity against muscarinic receptor subtypes in rat brain using [3H]OXO-M radioligand as a muscarinic receptor...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 9nMAssay Description:Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 33nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Muscarinic acetylcholine receptor M3 agonistic/antagonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:In vitro ability to displace [3H]quinuclidinyl benzilate [3H]QNB) from rat cortical Muscarinic acetylcholine receptor in competition assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a con...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 84nMAssay Description:Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Binding affinity against Muscarinic receptor M1 in rat brain using [3H]-PZ (pirenzepine) radioligand at a concentration of 1 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 113nMAssay Description:Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex.More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]PZ as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]QNB as a radioligand in the presence of Gpp(NH)p.More data for this Ligand-Target Pair
Affinity DataKi: 148nMAssay Description:Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
Affinity DataKi: 193nMAssay Description:Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)More data for this Ligand-Target Pair
Affinity DataKi: 196nMAssay Description:Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor in rat cortexMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 199nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]N-methylscopolamine binding in rat heartMore data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Displacement of [3H]3-quinuclidinyl benzilate ([3H]-QNB) from muscarinic acetylcholine receptor of rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataEC50: 270nMAssay Description:Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
Medical Research Division of American Cyanamid
Curated by ChEMBL
Medical Research Division of American Cyanamid
Curated by ChEMBL
Affinity DataKi: 324nMAssay Description:Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
Affinity DataIC50: 364nMAssay Description:Displacement of [3H]QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
