BDBM50005836 4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide::4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide::CHEMBL560739::CISAPRIDE::PROPULSID::US10167299, Cisapride::US10800776, Example Cisapride::US9221790, Cisapride::cid_5311047

SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC

InChI Key InChIKey=DCSUBABJRXZOMT-UHFFFAOYSA-N

Data  48 KI  43 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 50005836   

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 0.362nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.10nMAssay Description:Binding affinity to 5HT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.10nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  6.10nMAssay Description:The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.46nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.5nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.76nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Bovine)
Sandoz Pharma

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  7.20nMAssay Description:Compound was evaluated for the binding affinity at 5- HT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 9.80nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 2 receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  10.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  14.3nMAssay Description:Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of hERG in HEK293 cells by whole-cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  29nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  30nMAssay Description:The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 30nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
Sandoz Pharma

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  30nMAssay Description:Compound was evaluated for the binding affinity at Alpha adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human ERG potassium channel expressed in CHO cells by manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  32.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  39.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 39.8nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 39.8nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hERG potassium channel assessed as maximum inhibition rate at -80 mV holding potential incubated for 120 seconds by whole cell-automate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human ERG expressed in CHO cells assessed as whole cell current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  51.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  51.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  51.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataEC50:  55nMAssay Description:Agonism at 5HT4 receptor in rat tunica muscularis mucosaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataEC50:  55nMAssay Description:Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus stri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  62.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
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