BDBM50009568 (Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide::CHEMBL18981::N-((S)-1,2,3-Trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide::N-(1,2,3-Trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide::N-(1,2,3-Trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide (Thiocolchicine)::N-(1,2,3-Trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide(thiocolchicine)::THIOCOLCHICINE

SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c(OC)c1OC

InChI Key InChIKey=CMEGANPVAXDBPL-INIZCTEOSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009568   

TargetTubulin alpha-1A chain(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataKi:  700nMAssay Description:Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTubulin beta-2B chain(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory effect on the polymerization of purified bovine brain tubulin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin alpha-1A chain(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerizati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  1.40E+3nMAssay Description:Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  1.40E+3nMAssay Description:Ability to inhibit Tubulin polymerization in Bovine brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  4.90E+3nMAssay Description:Evaluated for the inhibition of tubulin polymerization without pre-incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50:  640nMAssay Description:Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed