BDBM50015004 CHEMBL3262372::US9259422, 7a, R = 2-thienyl- BU08026::US9480684, 7a, R = 2- thienyl- BU08026

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@](C)(O)c1cccs1)ccc3O

InChI Key InChIKey=ZVZIAWYLQBHCMQ-HETHIKCESA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50015004   

TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  0.600nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]diprenorphine from recombinant human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
The University of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  34.5nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  34.5nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]-N/OFQ from recombinant nociceptin opioid receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed