BDBM50027216 5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile::5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile::CHEMBL34166::VUF-2274

SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=MEEJEEVTIVAOJP-UHFFFAOYSA-N

Data  1 KI  6 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50027216   

TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataKi:  52nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor homolog US28(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
Vrije Universiteit

Curated by PDSP Ki Database
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor(Human cytomegalovirus)
Friedrich Alexander University

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulatory activity at FLAG-tagged human cytomegalovirus US28 receptor delta300 mutant expressed in HEK293T cells by PathDetectElk1 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor homolog US28(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
Vrije Universiteit

Curated by PDSP Ki Database
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataEC50:  4.57E+3nMAssay Description:Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor homolog US28(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
Vrije Universiteit

Curated by PDSP Ki Database
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataEC50:  4.50E+3nMAssay Description:Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor(Human cytomegalovirus)
Friedrich Alexander University

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataEC50: <1.00E+4nMAssay Description:Allosteric modulatory activity at FLAG-tagged human cytomegalovirus US28 receptor delta300 mutant expressed in HEK293T cells by PathDetectElk1 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor homolog US28(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
Vrije Universiteit

Curated by PDSP Ki Database
LigandPNGBDBM50027216(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Affinity DataEC50:  3.20E+3nMAssay Description:Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed