BDBM50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190
SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
InChI Key InChIKey=DFCJPPDAOZROBS-FKWFRFQNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 56 hits for monomerid = 50034922
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 793nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 228nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 1 receptorMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 0.930nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 71nMAssay Description:Agonist activity at mouse melanocortin-1 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.40nMAssay Description:Agonist activity at mouse melanocortin-4 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.60nMAssay Description:Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 56nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.80nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonistic activity evaluated at melanocortin 1 receptor (MC1R) of mouse HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonistic activity evaluated at melanocortin 4 receptor (MC4R) of mouse HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 10.2nMAssay Description:Functional activity at the mouse melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.46nMAssay Description:Functional activity at the mouse melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 25.6nMAssay Description:Functional activity at the mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 195nMAssay Description:Functional activity at the mouse melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.96nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-5 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 20.1nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-1 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 17.2nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-4 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-3 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 20.1nMAssay Description:Agonist activity to the mouse Melanocortin-1 receptor (mMC1R)More data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 3.96nMAssay Description:Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)More data for this Ligand-Target Pair
Affinity DataEC50: 17.2nMAssay Description:Agonist activity to the mouse Melanocortin-4 receptor (mMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 171nMAssay Description:In vitro agonist potency for Mouse Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 10.7nMAssay Description:In vitro agonist potency for Mouse Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.02nMAssay Description:In vitro agonist potency for Mouse Melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:In vitro agonist potency for Mouse Melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.26nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.28nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 126nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 3(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 7.10nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 3.90nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 4.30nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 548nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 290nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HTLA cells assessed as induction of beta-arrestin recruitment after 18 hrs by Presto-tango as...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 2 hrs by AlphaScr...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP ...More data for this Ligand-Target Pair