BDBM50035249 CHEMBL303892::N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy-2-isobutyl-malonamide

SMILES CC(C)CC(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O

InChI Key InChIKey=MSUGUYPTEWUYIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50035249   

TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(CHEMBL303892 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-et...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(CHEMBL303892 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-et...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(CHEMBL303892 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-et...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(CHEMBL303892 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-et...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed