BDBM50042493 CGS-23885::CHEMBL116719::N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea

SMILES NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1

InChI Key InChIKey=FPOBKZCHKXONBB-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50042493   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  37nMAssay Description:In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on 5-hydroxyeicosapentaenoic acid (5-HETE) productionMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  48nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  640nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory concentration against human platelet thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  3.60E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  890nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042493(CGS-23885 | CHEMBL116719 | N-hydroxy-N-[(6-phenoxy...)
Affinity DataIC50:  40nMAssay Description:In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails Article