BDBM50050412 5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL282948

SMILES Cc1c(CNc2cccc3CCCCc23)cnc2nc(N)nc(N)c12

InChI Key InChIKey=SVTGPTKXKFCHJW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50050412   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050412(5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylami...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050412(5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylami...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050412(5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylami...)
Affinity DataIC50:  142nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050412(5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylami...)
Affinity DataIC50:  0.930nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050412(5-Methyl-6-[(5,6,7,8-tetrahydro-naphthalen-1-ylami...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed