BDBM50059929 8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine::8-(3,4-dichlorophenyl)-9H-purine-2,6-diamine::CHEMBL312688

SMILES Nc1nc(N)c2[nH]c(nc2n1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=GZDRYQKQDXYCQK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50059929   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  2.52E+5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  2.52E+5nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  2.00E+4nMAssay Description:In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50059929(8-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine | 8-...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed